Cblb Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comCblb Polyclonal Antibody for Mouse(Mus musculus)

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Cblb (Gene name),

E3 ubiquitin-protein ligase CBL-B (Protein name ), CBLB_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cblb;

Protein name:

E3 ubiquitin-protein ligase CBL-B;

Alternative:

SH3-binding protein CBL-B;Casitas B-lineage lymphoma proto-oncogene b;Signal transduction protein CBL-B;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SH3 domain-containing proteins FYN, FGR, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin (By similarity). Interacts with SH3 domain-containing proteins VAV1, PLCG1, PIK3R1, LCK, CRK and SORBS1. May interact with CBL. Interacts with LCP2 and ZAP70.

Function:

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.

Subcellular Location:

Cytoplasm In adipocytes, translocates to the plasma membrane upon insulin stimulation.

Protein Attributes:

Sequence length:

982

Sequence:

50:

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950:

982:

RALEIAQNNV | EVARSILREF | AFPPPVSPRL | NL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q3TTA7

KEGG:

mmu:208650

String:

Q3TTA7

STRING:

10090.ENSMUSP00000023313

UniGene:

Mm.328206

Pfam:

PF02262

Uniprot:

Q3TTA7

FOR

ELISA Kit for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

E2531h

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96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

E2531m

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96T

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ELISA Kit for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

E2531r

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96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

U2531m

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Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

U2531h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

U2531r

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Packing:

96T

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

P2531Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

P2531Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL-B

Cat.:

P2531Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase CBL-B

Protein for Mouse E3 ubiquitin-protein ligase CBL-B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6J.
tissue: Testis.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells."
Krawczyk C. , Bachmaier K. , Sasaki T. , Jones R.G. , Snapper S.B. , Bouchard D. , Kozieradzki I. , Ohashi P.S. , Alt F.W. , Penninger J.M.
Immunity13:463-473(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b."
Bachmaier K. , Krawczyk C. , Kozieradzki I. , Kong Y.-Y. , Sasaki T. , Oliveira-dos-Santos A. , Mariathasan S. , Bouchard D. , Wakeham A. , Itie A. , Le J. , Ohashi P.S. , Sarosi I. , Nishina H. , Lipkowitz S. , Penninger J.M.
Nature403:211-216(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PIK3R1; LCP2; ZAP70; LCK; PLCG1 AND VAV1
5.

"Cbl-b regulates the CD28 dependence of T-cell activation."
Chiang Y.J. , Kole H.K. , Brown K. , Naramura M. , Fukuhara S. , Hu R.-J. , Jang I.K. , Gutkind J.S. , Shevach E. , Gu H.
Nature403:216-220(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
6.

"Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells."
Fang D. , Liu Y.-C.
Nat. Immunol.2:870-875(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination."
Zhang J. , Bardos T. , Li D. , Gal I. , Vermes C. , Xu J. , Mikecz K. , Finnegan A. , Lipkowitz S. , Glant T.T.
J. Immunol.169:2236-2240(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
8.

"The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport."
Liu J. , DeYoung S.M. , Hwang J.B. , O'Leary E.E. , Saltiel A.R.
J. Biol. Chem.278:36754-36762(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-664 AND TYR-708;INTERACTION WITH CBL; CRK AND SORBS1;SUBCELLULAR LOCATION
9.

"Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk."
Sohn H.W. , Gu H. , Pierce S.K.
J. Exp. Med.197:1511-1524(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;FUNCTION
10.

"Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction."
Jeon M.-S. , Atfield A. , Venuprasad K. , Krawczyk C. , Sarao R. , Elly C. , Yang C. , Arya S. , Bachmaier K. , Su L. , Bouchard D. , Jones R. , Gronski M. , Ohashi P. , Wada T. , Bloom D. , Fathman C.G. , Liu Y.-C. , more...
Immunity21:167-177(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-889;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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